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What is the explanation for the fact that CRH is very high,(39920 in F, 73086 in S) Vasopressin corrected is also high (172 in F, 124 in S) with low ACTH index (0.03 in F and 0.01 in S) and CI slightly decreased in S(5.2), slightly increased in F(7.21), normal oxitocyn.
In case of elevated cortisol index (in F and S) and CRH increased in F (normal in S), vasopressin corrected index normal in F (increased in S) with low ACTH index in normal F in S is there an alteration of feedback from the periphery to the hypothalamus and a desensitization of the pituitary gland to the action of CRH?
How can we differentiate between tissue resistance of cortisol and an impaired feedback in HPA axis? . Could elevated CRH be an expression of tissue resistance to cortisol and coexist with elevated cortisol index?If (in a postmenopausal state) there is a relative/absolute estrogen deficiency,in order to stimulate adrenal estrogen/DHEA production, what is the signal that causes DHEA secretion? CRH? This means that cortisol secretion will be stimulated at the same time, which may already be increased, causing the risk of worsening already pre-existing disorders? What would be the appropriate therapeutic attitude to balance/reduce peripheral secretion of androgens/estrogens of adrenal origin? (when both are raised – both those of gonadal origin and those of adrenal origin). If DHEA is increased secondary to stimulation due to HPA activation, does HPA activity need to be decreased? How can this be done directly? Indirectly, by decreasing central sympathetic activity I think.
Administration of beta-blockers with different selectivity on alpha /beta1-beta 2 receptors will influence the corresponding indices of the sympathetic nervous system? Is it useful to take blood sample before taking beta blockers?
How does the concomitant presence of treatments with SRAA inhibitors influence the endobiogenic assessment -( e.g. antialdosterones, ACE inhibitors,etc.)
Thyroid index as a ratio (between LDH and CK) X correction factor, could be calculated in the case of very high value of CK (secondary to physical strain)? In one case, I have introduced the value for CK (6000 U/L) in gemma report, and the value for Thyroid index was calculated with this high value. Is this right or there should be an upper limit for the CK and LDH in the operating system?
What is the meaning of low parasympathetic index and low parasympathetic index adjusted and how should we integrate these indexes in endobiogenic treatment?
Is it possible to be vagotonic (constitutionally) and to have a low parasympathetic index?
Is there a link between these indexes and the perception of safety of the organism?Thank you!
What is the role of the LDN (low-dose naltrexone) in the treatment of autoimmune disease from an endobiogenic point of view? Is there an indication guided by BetaMSH/alfaMSH index in conjunction with other indexes?
Is the treatment with metformin appropriate in a state characterized by low oxidation index, low redox index and insulin-resistance? We know that metformin inhibits Complex I of respiratory chain (inhibit oxidation), but this treatment is indicated (unfortunately) as the first line treatment in type II diabetes, independent of the oxido-reductive status?I find some discrepancies in normal value for same index in panel versus gemma (ex methabolic yield 80-140 vs 80-240). The value for the same index for one patient is different in gemma vs panel. The value for Thyroid yield is between 1,5-2,5 in books vs panel, where is between 2-3.
My question is about the normal value of cortisol/adrenal cortex index, between 1,2-2 in gemma and the normal/optimal value indicated in the book, vol 2 page 22, where “the ratio of the two indeces is about 2,5-3”, because the relation between two indexes is important in evaluate the corticotropic axes and for the choice of the right treatment; I don’t know which value should be used. In the book are presented some cases. If we consider cortisol/adrenal with a upper normal value of 2 , if cortisol index is normal in S and F, and adrenal is normal, cortisol/adrenal -is normal- 1,84 for gemma variant, but low if we consider the value in the book (normal between 2,5-3). Consequently, the interpretation would be very different. (I hope you understand my problem, because what we consider normal makes a huge difference in the interpretation the results). What is your recommandation?
